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etravirine will lower the extent or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.The level of medication which you choose is dependent upon the toughness in the medicine.